284 research outputs found
Cloud Migration: A Case Study of Migrating an Enterprise IT System to IaaS
This case study illustrates the potential benefits and risks associated with
the migration of an IT system in the oil & gas industry from an in-house data
center to Amazon EC2 from a broad variety of stakeholder perspectives across
the enterprise, thus transcending the typical, yet narrow, financial and
technical analysis offered by providers. Our results show that the system
infrastructure in the case study would have cost 37% less over 5 years on EC2,
and using cloud computing could have potentially eliminated 21% of the support
calls for this system. These findings seem significant enough to call for a
migration of the system to the cloud but our stakeholder impact analysis
revealed that there are significant risks associated with this. Whilst the
benefits of using the cloud are attractive, we argue that it is important that
enterprise decision-makers consider the overall organizational implications of
the changes brought about with cloud computing to avoid implementing local
optimizations at the cost of organization-wide performance.Comment: Submitted to IEEE CLOUD 201
The metabolism of progesterone
Section I. General Introduction • •
Section II. Method for the Quantitative Determination of small amounts of
Pregnanediol in Human Urine • •
Section III. Rapid Method for the Determination of Urinary Pregnanediol suitable
for routine clinical use • •
Section IV. The Conversion of Progesterone to Urinary Pregnanediol by Human
Subjects:
Introduction •
(1) Healthy Post -Menopausal Women •
(2) Healthy Young Men •
(3) Oestrogen pretreated Post-Menopausal Women •
(4) Hysterectomised Post-Menopausal Women •
(5) Hypertensive Cases •
(6) Administration of Pregnanediol or Sodium pregnanediol glucuronidate •
(7) Continued Daily Administration of Progesterone to Post-Menopausal Women and Young Men • •
Section V. Effect of Administration of Progesterone on Excretion of Pregnanediol during Normal Pregnancy • •
Section VI. Excretion of Urinary Pregnanediol after Excision of the Corpus Luteum of Pregnancy • •
Section VII. Effect of Diethylstilboestrol Administration on Excretion of Pregnanediol in Normal and Diabetic Pregnancy • •
Section VIII. Interpretation • •
References • •
Publication
Report and commentary on the following six cases: 1. Squamous epithelioma of maxillary sinus. 2. Squamous epithelioma of mandible. 3. Recurrent sq.epith. of tongue. 4. Recurrent sq.eapillomata of tongue with syphilitic glossitis and leucoplakia. 5. Recurrent squamous epithelioma of tonsil. 6. Leucoplakia and recurrent squamous epithelioma of vulva: Pattison Prize in Clinical Surgery, 1946
The cases in the Report, by illustrating
a series of definite aetioloical factors, suggest
a line of attack not usually available in the treatment
of neoplasms, namely, prophylaxis.Adequate treatment and follow up of cases of
a Syphilitic Globsitis; early recognition and treatment
of Buccal Leukoplakia (and especially of
Leukoplakia Vulvae); the avoidance of prolonged
dental trauma and serious consideration of resultant "simple" ulceration; the recognition of
treatment of nutritional anaemia, all these may
reduce the incidence of Succal Carcinoma despite
the ever increasing number of candidates in an
ageing population
Decision Support Tools for Cloud Migration in the Enterprise
This paper describes two tools that aim to support decision making during the
migration of IT systems to the cloud. The first is a modeling tool that
produces cost estimates of using public IaaS clouds. The tool enables IT
architects to model their applications, data and infrastructure requirements in
addition to their computational resource usage patterns. The tool can be used
to compare the cost of different cloud providers, deployment options and usage
scenarios. The second tool is a spreadsheet that outlines the benefits and
risks of using IaaS clouds from an enterprise perspective; this tool provides a
starting point for risk assessment. Two case studies were used to evaluate the
tools. The tools were useful as they informed decision makers about the costs,
benefits and risks of using the cloud.Comment: To appear in IEEE CLOUD 201
Academic Cloud Computing Research: Five Pitfalls and Five Opportunities
This discussion paper argues that there are five fundamental pitfalls, which
can restrict academics from conducting cloud computing research at the
infrastructure level, which is currently where the vast majority of academic
research lies. Instead academics should be conducting higher risk research, in
order to gain understanding and open up entirely new areas.
We call for a renewed mindset and argue that academic research should focus
less upon physical infrastructure and embrace the abstractions provided by
clouds through five opportunities: user driven research, new programming
models, PaaS environments, and improved tools to support elasticity and
large-scale debugging. The objective of this paper is to foster discussion, and
to define a roadmap forward, which will allow academia to make longer-term
impacts to the cloud computing community.Comment: Accepted and presented at the 6th USENIX Workshop on Hot Topics in
Cloud Computing (HotCloud'14
Responsibility Modeling for the Sociotechnical Risk Analysis of Coalitions of Systems
Society is challenging systems engineers by demanding ever more complex and
integrated systems. With the rise of cloud computing and systems-of-systems
(including cyber-physical systems) we are entering an era where mission
critical services and applications will be dependent upon
'coalitions-of-systems'. Coalitions-of-systems (CoS) are a class of system
similar to systems-of-systems but they differ in that they interact to further
overlapping self-interests rather than an overarching mission. Assessing the
sociotechnical risks associated with CoS is an open research question of
societal importance as existing risk analysis techniques typically focus on the
technical aspects of systems and ignore risks associated with coalition
partners reneging on responsibilities or leaving the coalition. We demonstrate
that a responsibility modeling based risk analysis approach enables the
identification of sociotechnical risks associated with CoS. The approach
identifies hazards and associated risks that may arise when relying upon a
coalition of human/organizational/technical agents to provision a service or
application. Through a case study of a proposed cloud IT infrastructure
migration we show how the technique identifies vulnerabilities that may arise
because of human, organizational or technical agents failing to discharge
responsibilities.Comment: Submitted for consideration for the IEEE SMC2011 conferenc
- …